Already on Parkinson’s therapy like VYALEV?
Here is where a gut-brain probiotic fits in.
Already on Parkinson’s therapy like VYALEV?
Here is where a gut-brain probiotic fits in.
Living with Parkinson's means navigating a condition that touches far more than movement. For people using a therapy like VYALEV, you already know daily management is ongoing and real.
Neuralli® MP is a probiotic medical food for the dietary management of Parkinson's disease, taken under the supervision of a health care provider. It's built around PS128, which is a probiotic strain that acts through the gut-brain axis: not to change your digestion, but to influence the brain. In fact, in preclinical studies, PS128 was shown to increase dopamine in the brain.
Neuralli MP is designed to work alongside your existing therapy, not replace it. A therapy like VYALEV delivers levodopa to help manage motor symptoms. Neuralli MP affects the brain differently, likely by influencing dopamine metabolism or signalling. In a single-arm study, people with Parkinson's taking PS128™ (60 billion CFU/day, the clinical-study dose) alongside their levodopa reported improvements in their motor scores and "on" and "off" times.
If you're already doing the work of managing Parkinson's, Neuralli MP is one more gut-brain tool to talk through with your doctor.
Two different jobs
The first thing to understand is that VYALEV and Neuralli MP are not competing for the same role.
VYALEV (carbidopa and levodopa) is a gel administered subcutaneously, designed to provide steady levodopa delivery, which may help reduce the “off periods” that come with oral levodopa. It manages the motor dimension of Parkinson's.
Neuralli MP works differently. It is a medical food that contains PS128, a probiotic strain studied for its potential role in supporting the gut-brain axis
How Neuralli MP can impact your day
PS128 is a strain of L. plantarum that has been studied more specifically for gut-brain outcomes.
In a pilot study of adults with Parkinson's disease who took PS128 for 12 weeks, 68% of participants reported an improvement in quality of life as well as improvements in the following:
- Motor scores with reduced "off" time
- Motor scores with longer "on" time
Neuralli MP is formulated at 60 billion CFU of PS128 per serving, the dose used in the clinical research. It is designed to fit into the day without friction.
For someone already managing a complex Parkinson's care routine, it is one small addition, not an overhaul.
Neuralli MP is a medical food intended for the dietary management of Parkinson's disease and is to be used under medical supervision.
How VYALEV and Neuralli work differently
VYALEV and Neuralli MP work on different parts of the same condition; taking either of them would be best advised under the supervision of your healthcare provider.
Bring it up with your doctor
Neuralli MP is a medical food and is intended to be used under medical supervision. If you are already working with a neurologist or movement disorder specialist, they are the right person to talk to about adding Neuralli MP to your routine.
You can show them this article. You can bring the research. PS128's clinical data is available, and your care team can review it alongside everything else they know about your situation.
What people are saying about Neuralli MP
“Neuralli has greatly improved my life. I have had Parkinson's for about 14 years and I am on the regular, standard Parkinson's medications. I can not complain, I felt like I was doing very well. But after taking Neuralli now know what feeling BETTER is. … Overall I feel much more at ease and happier. Being a woman at 65 these are all great significant improvement. Thank You Neuralli MP for such a great product!” - Micolette H.
“It helped me with off times from Parkinson” - Joseph R.
“I started taking PS128 probiotic 4 weeks ago. Within a week I noticed I wasn’t getting off period symptoms from PD. I’m feeling improved motor function and reduced bradykenesia” - Dr. S.
Start here
Neuralli MP is a medical food, and is available without a prescription, though it is intended for use under medical supervision.
Frequently asked questions
What is Neuralli® MP?
Neuralli® MP is a probiotic medical food for the dietary management of autism and Parkinson's disease, intended for use under the supervision of a healthcare provider.
Each two-capsule serving delivers at least 60 billion CFU of the gut-brain strain L. plantarum PS128TM, Bened Life's highest PS128 potency. It is believed to work via the gut-brain axis: PS128 affected serotonin and dopamine in the brain in preclinical studies.
What's the difference between Neuralli® MP and a regular probiotic or supplement?
Neuralli® MP is a medical food, not a dietary supplement or a drug. Its main ingredient, the L. plantarum PS128TM probiotic strain, has been studied primarily for its impact on the brain, not the gut.
Through the ability of PS128 to support gut microbiome-to-brain communication, Neuralli MP provides dietary management for autism and Parkinson’s disease.
In preclinical studies, PS128 influenced levels of dopamine and serotonin in the brain. Autism and Parkinson’s have dysregulated serotonin and/or dopamine in the brain. PS128 acts like a microbe-nutrient to meet the dietary needs of these conditions. PS128 cannot be obtained by dietary modification alone.
Where can I find the clinical studies about PS128TM?
L. plantarum PS128TM, the active ingredient in Neuralli® MP, has been clinically studied in Autistic people, as well as people with Parkinson's disease. Summaries of the scientific research studies can be found here.
Visit our Neuralli® MP FAQs page for more information!