Published Research
Clinical Studies
Neurodevelopment
L. plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience
Significant improvements for autism patients taking PS128, more than other probiotics
Overall improvement for autism patients from PS128 and oxytocin combination therapy
Alleviated ADHD and other symptoms of autism in children
Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
ADHD symptoms significantly decreased in children with Tourette syndrome taking PS128
Neurodegeneration
Mental Health
Depressive thoughts, feelings, and other symptoms significantly decreased
Improved depressive symptoms and sleep quality
Benefited anxiety, stress, and insomnia in highly-stressed office workers
Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders
Better outcomes and fewer adverse effects from PS128 + SSRI (citalopram) than with SSRI alone
Exercise Performance
Effect of Daily Oral L. plantarum PS128 on Exercise Capacity Recovery after a Half-Marathon
Faster split times and increased lower leg strength in recreational runners
L. plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation
Benefits to exercise recovery and athletic performance in athletes
The Beneficial Effects of L. plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes
Improved oxidative stress, exercise performance, and serum BCAA levels in athletes
Preclinical Studies
Neurological Function
PS128 protected against Alzheimer's disease in mice
L. plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis
PS128 regulated dopamine and reduced Tourette syndrome-like behavior in rats
PS128 was comparable and lasted longer than PD treatment, DBS in improving Parkinson's indicators in rats
PS128 enhanced dopamine and BDNF, reduced Parkinson’s disease-like symptoms in mice
Alteration of behavior and monoamine levels attributable to L. plantarum PS128 in germ-free mice
PS128 regulated dopamine and serotonin levels, improved anxiety-like behaviors
Psychotropic effects of L. plantarum PS128 in early life-stressed and naïve adult mice
PS128 lowered behaviors of anxiety and depression, regulated related dopamine and serotonin in mice