Frequently Asked Questions

Neuralli® MP (formerly NeuralliTM)

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General Questions

What form does Neuralli MP come in?

Neuralli MP comes in capsules packaged in a twist-off bottle. These state-of-the-art CSP vials keep the inside of the bottle very dry and help maintain maximum probiotic potency.

I can't take pills - how can I take Neuralli MP?

If swallowing the capsule is uncomfortable, you can open the shell and take the powder. (Take it all at once to guarantee its potency.) If you’d like, you can mix Neuralli MP powder into a cool drink or food of your choice. It should not be added to warm/hot foods or liquids. Read more here

Is Neuralli MP MFDA approved?

The FDA approves drugs (or medicines). Neuralli MP is not a drug or medicine. It is a medical probiotic, which is a type of medical food.

A medical food is defined by 21U.S. Code 360 ee, (b), (3), section 5(b) as a food formulated to be consumed or administered enterally under the supervision of a physician for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.

Neuralli MP is a medical probiotic intended to support the dietary management of autism, anxiety, depression, and Parkinson’s Disease. Lactiplantibacillus (formerly Lactobacillus) plantarum PS128 is the probiotic strain that, at sufficiently high quantities, when administered to the people with the specified neurological conditions, has demonstrated some benefits that are clinically meaningful.

L. plantarum PS128 is affirmed as generally recognized as safe (GRAS). The strain L. plantarum PS128 is derived from a fermented food. The fermented food itself is not in a typical diet and does not have the standardized quantities of the specific strain, PS128. To maintain the strain's genetic integrity, it must be cultivated in controlled manufacturing conditions. To deliver a sufficient quantity to have a clinically meaningful effect, Neuralli MP delivers PS128 in a high-potency form.

What are the common side effects?

When taking Neuralli MP as directed, some people may experience mild gastrointestinal upset such as gas, bloating, or stool changes for up to a week, just as when starting any new probiotic. Reports of adverse effects by autistic study participants and patients with Parkinson’s disease in four clinical studies were very low. If symptoms persist, we recommend consulting your health care provider.

Can my child take Neuralli MP?

Children as young as 3 years of age have used 60 billion CFUs per day of PS128 in clinical studies. Please keep in mind that since each child is different, dosage may vary. Kindly review the labeling to ensure Neuralli MP is right for your child, and consult your health care professional.

Neuralli MP is a medical food intended to be used under the supervision of a health care professional.

Does Neuralli MP help with constipation?

Neuralli MP helps support healthy intestinal microbiota. Bowel functions vary among individuals, of course, so please consult with your health care professional to discover how Neuralli MP might help maintain your digestive health.

What happens if I stop taking Neuralli MP for a few days?

Neuralli MP is most effective when taken daily. The benefits of Neuralli MP come from its probiotic strain, and the strain itself doesn’t colonize in your gut. Therefore, if you don’t take it, you will not be getting the good bacteria. That said, if you miss a day, there’s no need to take a double dose to make up for it. Simply start again the next day.

Does PS128 colonize the gut?

It is unknown if PS128 can reproduce within the human intestine. Unpublished research shows that PS128 DNA could be detected in the stool of some volunteers for 1-2 weeks after taking the strain. However, it is not known if PS128 was alive and reproducing within the intestine over that period.

Probiotics typically provide benefits as they are taken and pass through the intestine. It is not necessary for them to “colonize” the gut in order to be effective. It is rare for any probiotic strain to be retained in the gut once a person stops taking it.

You can read more about probiotic colonization in this article from the International Scientific Association for Probiotics and Prebiotics (ISAPP):

What goes into the cost of Neuralli MP?

Because Neuralli MP is not shelf stable, we formulate, package, and ship it carefully. We don’t compromise in our pursuit of providing maximum potency for maximum benefit. We add in more than 30 billion CFUs at the time of manufacturing to ensure you get at least 30 billion CFUs per capsule through the best by date. We use special CSP vials to keep the capsules dry. We ship fast and cold to prevent CFU loss, and use robust curbside recyclable insulated packaging to minimize our impact on the environment.

At Bened Life, we believe that safe and effective microbiome solutions are part of the answer. Your investment in Neuralli MP supports our mission to unlock the gut-brain axis and make an impact on the communities we serve.

What are the ingredients in Neuralli MP?

Neuralli MP contains L. plantarum PS128 , inulin, microcrystalline cellulose, silicon dioxide, magnesium stearate, and vegetable capsule (hydroxypropyl methylcellulose and water).
Each serving (2 capsules) contains at least 60 billion CFUs of L. plantarum PS128 and 180 mg of inulin from chicory root or Jerusalem artichoke.

Getting started with Neuralli MP

How should I store Neuralli MP? Does it need to be refrigerated?

To keep your products maximally effective, store them in their original CSP bottles in the refrigerator. Be sure to keep Neuralli MP in its original bottle to limit the exposure of the capsules to humidity; do not store the capsules in a different container. Do not expose Neuralli MP to high heat or direct sunlight.

If you travel with Neuralli MP, always keep it in a cool, dry place. Storing a bottle at a consistent room temperature for up to one month will not impact the efficacy of the product.


When should I take Neuralli MP?

Take two capsules every day. Many customers take both at the same time; however, you can also split them up if you prefer. Find the time of day that works best for you.

In a clinical study with people with Parkinson’s disease, participants took two capsules in the evening. In other clinical studies the timing was left up to the participants.

How many Neuralli MP capsules should I or my child take per day?

The serving size of Neuralli MP is 2 capsules per day, providing 60 billion CFU of PS128. Children as young as 3 years of age have used 60 billion CFUs per day of PS128 in clinical studies.

Since each person is different, your tolerance may vary. Please take Neuralli MP under the supervision of your health care provider.

Can I take more than two Neuralli MP capsules daily?

Most adults take 1-2 capsules per day. Please keep in mind that because each person has a unique bacterial ecosystem, dosage may vary, but more is not necessarily better. Review the label to ensure Neuralli MP is right for you and consult your health care professional if you have any questions.

My box didn’t contain ice packs, or the ice packs were melted. Should I be concerned?

You may receive your product in a box with or without cold packs, depending on the time of year and your geographic location. If your package contains cold packs that are no longer cold, or perhaps even warm, when the box arrives at your door, don’t worry - your product is safe. Simply refrigerate all bottles right away.

Bened Life products are stable under most shipping conditions, but should be refrigerated upon receipt. PS128 requires refrigeration to retain efficacy through its best-by date.

If you happen to experience an unexpected heat wave or unusual circumstances such as product sitting at your door in excessive heat for an extended period of time, please contact our customer happiness team through our contact form.

Medical conditions and medications

I have a medical condition. Can I take Neuralli MP ?

As a medical food, Neuralli MP should be used under the supervision of your health care provider. Its active ingredient, PS128, has been studied in Autistic people and people with Parkinson’s, anxiety, and depression (see references here).

PS128 may play a role in modulating neurotransmitters such as dopamine and serotonin in some individuals. If you have concerns about this, please speak with your health care provider before starting or stopping Neuralli MP.

While each ingredient in Neuralli MP is generally recognized as safe (GRAS), Neuralli MP has not been tested for safety and effectiveness in populations with other medical conditions. We recommend that you consult with your health care provider to decide if Neuralli MP is right for you.

Can I take Neuralli MP if I'm pregnant or breastfeeding?

If you are breastfeeding or pregnant, we recommend speaking to your health care provider for guidance. They will have the best recommendations for you with your health history in mind.

Does Neuralli MP interfere with SSRI's?

We always recommend consulting with your health care provider before starting any new medical food, supplement, or medication. A recent study that looked at the use of L. plantarum PS128 in patients with anxiety disorders found that the combination of anti-anxiety medication and PS128 led to fewer adverse events than taking the SSRI on its own. However, your experience may differ. Please take Neuralli MP under the supervision of your health care provider.

Can I take Neuralli MP with antibiotics?

Some antibiotics may make Neuralli MP less effective. If you are taking an antibiotic, please consult your health care professional for advice.

I’m sensitive to histamine. Is PS128 a histamine-producing probiotic?

L. plantarum PS128 does not produce histamine. It does not have the histidine decarboxylase (hdc) gene in its genome.

Neuralli MP and PS128 science

Is Neuralli MP backed by published, peer-reviewed science?

Yes, the powerful probiotic strain in Neuralli MP has been the focus of multiple research and clinical studies. The strain Lactobacillus plantarum PS128 was isolated after a rigorous screening process of nearly one thousand strains of bacteria. These strains were tested for potency, effectiveness, and the ability to affect mental wellness. PS128 was proven to strengthen the immune and digestive systems, as well as improve mental health by modulating stress, reducing anxiety, and promoting a balanced mood. Click here for more information about the science of Neuralli MP. You can view the clinical studies about PS128 here.

How is PS128 different from any other strain of L. plantarum? Will other L. plantarum strains have the same effect?

While many strains of L. plantarum are commercially available as probiotics, the L. plantarum PS128 strain has proved to be neurologically active in preclinical trials.

In general, different strains of a single bacterial species can have very different beneficial effects. For example: L. plantarum UALp-05 may be beneficial for people with IBS. Lactobacillus plantarum LPLDL can help with cholesterol levels. Lactobacillus plantarum TWK10 may help retain muscle mass in aging athletes.

What’s the difference between taking PS128 and eating lacto-fermented vegetables?

PS128 was discovered in spontaneously fermented mustard greens after screening over 1000 lactic acid bacteria for gut-brain potential. There are a lot of foods that contain live microorganisms. However, the CFU count of any specific microorganism strain that happens to be in a fermented vegetable doesn't reach the 30 billion CFU total that is in each capsule of Neuralli MP. The specificity of strains can vary in sauerkraut, and CFU count may range, for example, from 1,000 to 100 million CFUs of all strains per gram. When you compare this to the 60 billion CFUs of PS128 in the daily serving of Neuralli MP, it adds up to a minor amount.

Your choice of probiotic should also be based on evidence-based trials of efficacy on specific strains or formulations. In the case of PS128, research-based single-strain probiotics can be particularly powerful, as they are more targeted and offer researched benefits from the specific strain.

What are psychobiotics?

An expansion to the term probiotic, psychobiotics are defined as live microorganisms that when administered at adequate amounts, provide a mental health benefit. Neuralli MP contains the novel psychobiotic L. plantarum PS128, clinically shown to provide both neurological and mental health benefits, likely due to its influence on the production and/or metabolism of serotonin and dopamine.

What is a medical probiotic?

A medical probiotic is a type of medical food. The term medical food, as defined in the Orphan Drug Act, is "a food which is formulated to be consumed or administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation."

Neuralli MP is a medical probiotic, specific to neurological and mental health. In Neuralli MP’s case, this term encompasses Neuralli MP’s active ingredient L. plantarum PS128 being a probiotic, psychobiotic, and medical food clinically shown to provide neurological and mental health benefits.

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