What is Parkinson's disease?

Parkinson's disease (PD) is the second most common neurodegenerative disorder and the fastest growing in the world, with a current global incidence of 10 million and 90,000 being diagnosed in the US each year - a rate that is only consistently increasing.

PD is characterized by impaired motor control alongside other nonmotor symptoms. Common characteristics of PD include:

  • Difficultly in balance and coordination
  • Rigidity
  • Shaking or tremors
  • 'Poker face' (facial rigidity)

Contrary to popular belief, PD is not exclusively associated with old age, with young-onset Parkinson's disease (YOPD) - occuring as young as 40 years old - being increasignly common.

One very common early symptom for PD is constipation, which affects 90% of PD patients and occurs up to 10 years before the common motor characteristics start to manifest. This nonmotor symptom highlights the popular hypothesis that PD begins in the gut.

The Gut and Parkinson’s

Called the 'Second Brain' - having the second largest number of neurons besides our brain, our gut is connected to the brain via the Gut-Brain Axis (GBA). This is why we have “butterflies” in our stomach when we are nervous.

Unfortunately, gut issues such as constipation impact people with Parkinson’s disease (PD) on a daily basis. Low amounts of good bacteria have contributed to dopamine and serotonin imbalances, and unwanted symptoms. Patients with severe, later stages of PD may develop motor symptoms such as tremors and slowness of movements (bradykinesia).

Interestingly, research shows that treating the gut with Neurobiotics can help balance neurotransmitters such as dopamine, significantly improving the quality of life of those with PD.

Called the 'Second Brain' - having the second largest number of neurons besides our brain, our gut is connected to the brain via the Gut-Brain Axis (GBA). This is why we have “butterflies” in our stomach when we are nervous.

Unfortunately, gut issues such as constipation impact people with Parkinson’s disease (PD) on a daily basis. Low amounts of good bacteria have contributed to dopamine and serotonin imbalances, and unwanted symptoms. Patients with severe, later stages of PD may develop motor symptoms such as tremors and slowness of movements (bradykinesia).

Interestingly, research shows that treating the gut with Neurobiotics can help balance neurotransmitters such as dopamine, significantly improving the quality of life of those with PD.

Can probiotics help PD patients?

For PD patients, a medical probiotic that provides the missing microbes needed for signaling from the gut to the brain could result in clinically meaningful differences in their quality of life. Not all probiotics are the same, so a PD patient, with the supervision of a health care practitioner, could consider a probiotic that has been tested in PD and shown to produce benefits.

The gut and brain can influence each other through the activity of neurotransmitters like serotonin and dopamine. The core pathophysiology of PD is the death of dopaminergic neurons in the brain. Neurobiotics specifically appear to modulate the level of neurotransmitters. Interestingly, Lactobacillus plantarum PS128, as of this writing, may be the only probiotic strain known to increase dopamine activity in the brain, which is a critical factor in PD.

“Happier Gut, Healthier Mind.”

The Neurobiotic - L. plantarum PS128

Probiotics are live microorganisms, which can tip the balance of the gut microbiome, and are known for providing health benefits. But neurobiotic strains like L. plantarum PS128 - naturally isolated from the fermented vegetable Fu-Tsai - go further, providing benefits for those with Parkinson's disease, Autism, ADHD, and Depression.

“Unlike pharmaceuticals merely overpowering our bodies’ functions, the fermented food-derived PS128 gently works with our microbiome.”

PS128 clinical data on PD patients

The efficacy of PS128 preclinical studies on PD was immediately proven in a recent clinical study. PD patients taking PS128 showed significant improvements in motor symptoms, including a prolonged ‘ON’ period and reduced ‘OFF’ period, and overall quality of life.

When anti-Parkinsonian medications such as Levodopa are working as intended, it is known as the 'ON' period. When the effect of the medication wears off, it is known as the 'OFF' period.

PD patients who took PS128 showed significant improvements in motor scores during both ON and OFF periods when compared to the baseline. In addition, taking PS128 lengthened the ON period and shortened the OFF period when compared to baseline.

For more science information

Learn How PS128 can Help with Neurological Disorders

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Bened Life

Derived from the Latin root “benedicere”, which means “blessed” or “full of blessings”, the Bened Life team comes from all walks of life, united by a common mission to advance science, improve health, and build a sensory inclusive world. And KultureCity, an NGO for neurodiverse people, has been a partner for our dream.

Bened Life is dedicated to promoting neurological and mental health with pharma-grade brain probiotics, backed by over 30 years of research experience, and clinical studies. With Neuralli, we are making meaningful impact on individuals and families globally.

“Let’s have a world where one can thrive regardless of how one perceives the world -
a world where we all can all truly live a bened life.”

Neuralli® MP

 

Each serving (2 caps.) of Neuralli MP contains 60 billion CFUs of PS128 - a specific amount one can’t get from eating food alone. Neuralli MP is a safe and nautral product - it does not contain any additives and is free of 14 common allergens. It is also considered as “generally recognized as safe” (GRAS) to consume.

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How do I use the pills as a powder?

Swallowing the pills is not the only way to take Neuralli MP - you can also use the contents of the capsules in powder form. Neuralli MP capsules can be twisted and then pulled open.

Open the capsules over the cold food or drink that you wish to mix it with so you don’t lose any of the powder. We do not recommend mixing Neuralli MP powder into hot foods or liquids, as it will decrease the potency of Neuralli MP.

Mix thoroughly and consume within a few minutes for best results.

“The first and leading gut-brain medical probiotic from the United States for ADHD,

Autism, Depression, and Parkinson’s.”

Neuralli MP can be taken as easy-to-swallow capsules or opened and mixed into cold liquids or foods.

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To see if Neuralli works for you, please consider 2-month trial or more.
Neuralli contains the unique neurologically active probiotic strain L. plantarum PS128.
PS128 was administered for 2 or more months in all but one clinical study**.



**In studies of people with neurological conditions.

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What People Say

More Laughter

We are only two weeks in, but I have seen an improvement in my son’s mood. I hear more laughter than I did before. So I am sure we are headed in the right direction.

Jennifer F

Thank You!

At one month in I am amazed at the positive benefits my body seems to be getting.

Barbara A.

So Thankful to Find This

[My daughter] said she feels more even-keeled, more positive, better rested and less anxious. I am noticing a significant improvement in her ability to handle stress which would normally result in meltdowns. This probiotic really seems to be making a difference for her.

K. T.

Honestly Life Altering

Amazing product. It has improved my mood tremendously and allowed me to find more joy in each day. Highly recommend. Worth every penny.

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Did you know…?

What is Neuralli MP?

Neuralli MP, as its name suggests, is a medical probiotic specific to neurological and mental health. Neuralli MP’s active ingredient, L. plantarum PS128, is able to provide clinically meaningful improvements for people with neurological conditions such as Parkinson's disease. Neuralli MP is a medical probiotic because it is a medical food, which is intended for use under the supervision of a physician and provides dietary management for neurological conditions such as PD.

Can I take Neuralli MP with other supplements or probiotics?

Neuralli MP can be taken with most other probiotics. Use caution when combining Neuralli MP with any other substance that affects levels of serotonin, dopamine, or cortisol. Contact your health care provider if you have any concerns about interactions with other products you are taking or if you have any health conditions.

How do I take Neuralli MP?

Parkinson's patients can take 2 capsules a day - which contains the same serving used in clinical studies. If swallowing the capsule is uncomfortable, you can open the shell and take the powder. (Take it all at once to guarantee its potency.) If you’d like, you can mix Neuralli MP powder into a cool drink or food of your choice. It should not be added to warm/hot foods or liquids.

How long will it take to notice results?

Noticeable results varies between individuals. 70% of people who took Neuralli MP for 2+ months improved their quality of life, based on 70 customer survey respondents. You may notice changes within the first week, or it may require 2 or more months to notice results, as evidenced by clinical studies of PS128.

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