Frequently Asked Questions

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General Questions

What form does Neuralli come in?

Neuralli comes in capsules packaged in a twist-off bottle. These state-of-the-art CSP vials keep the inside of the bottle very dry and help maintain maximum probiotic potency.

I can't take pills - how can I take Neuralli?

If swallowing the capsule is uncomfortable, you can open the shell and take the powder. (Take it all at once to guarantee its potency.) If you’d like, you can mix Neuralli powder into a cool drink or food of your choice. It should not be added to warm/hot foods or liquids. Read more here

Is Neuralli FDA approved?

The FDA approves drugs and medicines. Neuralli is not a drug or medicine. It is a daily medical probiotic, which is a type of medical food. It is backed by 12 clinical studies and is affirmed to be generally recognized as safe .

What are the common side effects?

When taking Neuralli as directed, some people may experience mild gastrointestinal upset such as gas, bloating, or stool changes for up to a week, just as when starting any new probiotic. Reports of adverse effects by autistic study participants and patients with Parkinson’s disease in four clinical studies were very low. If symptoms persist, we recommend consulting your health care provider.

Can my child take Neuralli?

Children as young as 3 years of age have used 60 billion CFUs per day of PS128 in clinical studies. Please keep in mind that since each child is different, dosage may vary. Kindly review the labeling to ensure Neuralli is right for your child, and consult your health care professional if you have any questions.

Does Neuralli help with constipation?

Neuralli helps support healthy intestinal microbiota. Bowel functions vary among individuals, of course, so please consult with your health care professional to discover how Neuralli might help maintain your digestive health.

What happens if I stop taking Neuralli for a few days?

Neuralli is most effective when taken daily. The benefits of Neuralli come from its probiotic strain, and the strain itself doesn’t colonize in your gut. Therefore, if you don’t take it, you will not be getting the good bacteria. That said, if you miss a day, there’s no need to take a double dose to make up for it. Simply start again the next day.

Does PS128 colonize the gut?

It is unknown if PS128 can reproduce within the human intestine. Unpublished research shows that PS128 DNA could be detected in the stool of some volunteers for 1-2 weeks after taking the strain. However, it is not known if PS128 was alive and reproducing within the intestine over that period.

Probiotics typically provide benefits as they are taken and pass through the intestine. It is not necessary for them to “colonize” the gut in order to be effective. It is rare for any probiotic strain to be retained in the gut once a person stops taking it.

You can read more about probiotic colonization in this article from the International Scientific Association for Probiotics and Prebiotics (ISAPP):

What goes into the cost of Neuralli?

Because Neuralli is not shelf stable, we formulate, package, and ship it carefully. We don’t compromise in our pursuit of providing maximum potency for maximum benefit. We add in more than 30 billion CFUs at the time of manufacturing to ensure you get at least 30 billion CFUs per capsule through the best by date. We use special CSP vials to keep the capsules dry. We ship fast and cold to prevent CFU loss, and use robust curbside recyclable insulated packaging to minimize our impact on the environment.

At Bened Life, we believe that safe and effective microbiome solutions are part of the answer. Your investment in Neuralli supports our mission to unlock the gut-brain axis and make an impact on the communities we serve.

What are the ingredients in Neuralli?

Neuralli contains L. plantarum PS128 , inulin, microcrystalline cellulose, silicon dioxide, magnesium stearate, and vegetable capsule (hydroxypropyl methylcellulose and water).
Each serving (2 capsules) contains at least 60 billion CFUs of L. plantarum PS128 and 180 mg of inulin from chicory root or Jerusalem artichoke.

Getting started with Neuralli

How should I store Neuralli? Does it need to be refrigerated?

Neuralli is not shelf stable. We ship cold and fast to preserve maximum potency, and we advise you to refrigerate Neuralli as soon as it arrives for maximum efficacy through the "best by" date.

If you travel with Neuralli, always keep it in a cool dry place. While you should store Neuralli in the refrigerator as much as possible, up to two weeks at room temperature or a few days at up to 99°F will not impact its potency significantly. Each capsule of Neuralli is packed with more than 30 billion CFUs to account for any loss that may occur during transport and storage.

Be sure to keep Neuralli in its original bottle to limit the exposure of the capsules to humidity; do not store the pills in a different container.

When should I take Neuralli?

Take two capsules every day, both at the same time if possible. Based on clinical studies, we recommend autistic people take two capsules of Neuralli every day in the evening. You can also split the dose and take one pill in the morning and the second in the evening. If you take Neuralli at a different time one day than the other, the efficacy will not be compromised. We recommend people with Parkinson’s disease take two capsules at the same time, preferably in the evening on an empty stomach.

Can I take more than two Neuralli capsules daily?

Most adults take 1-2 capsules per day. Please keep in mind that because each person has a unique bacterial ecosystem, dosage may vary, but more is not necessarily better. Review the label to ensure Neuralli is right for you and consult your health care professional if you have any questions.

My ice packs arrived melted. Should I be concerned?

Ice packs may arrive melted. They are added to reduce overall temperature exposure during travel, but Neuralli does not need to arrive cold. Neuralli can travel at temperatures up to 99° F. Refrigerate Neuralli as soon as possible after receipt of your package.

Medical conditions and medications

I have a medical condition. Can I take Neuralli?

As a medical food, Neuralli should be used under the supervision of your health care provider. Its active ingredient, PS128, has been studied in Autistic people and people with Parkinson’s, anxiety, and depression (see references here).

PS128 may play a role in modulating neurotransmitters such as dopamine and serotonin in some individuals. If you have concerns about this, please speak with your health care provider before starting or stopping Neuralli.

While each ingredient in Neuralli is generally recognized as safe (GRAS), Neuralli has not been tested for safety and effectiveness in populations with other medical conditions. We recommend that you consult with your health care provider to decide if Neuralli is right for you.

Can I take Neuralli if I'm pregnant or breastfeeding?

If you are breastfeeding or pregnant, we recommend speaking to your health care provider for guidance. They will have the best recommendations for you with your health history in mind.

Does Neuralli interfere with SSRI's?

We always recommend consulting with your health care provider before starting any new medical food, supplement, or medication. A recent study that looked at the use of L. plantarum PS128 in patients with anxiety disorders found that the combination of anti-anxiety medication and PS128 led to fewer adverse events than taking the SSRI on its own. However, your experience may differ. Please take Neuralli under the supervision of your health care provider.

Can I take Neuralli with antibiotics?

Some antibiotics may make Neuralli less effective. If you are taking an antibiotic, please consult your health care professional for advice.

I’m sensitive to histamine. Is PS128 a histamine-producing probiotic?

L. plantarum PS128 does not produce histamine. It does not have the histidine decarboxylase (hdc) gene in its genome.

Neuralli and PS128 science

Is Neuralli backed by published, peer-reviewed science?

Yes, the powerful probiotic strain in Neuralli has been the focus of multiple research and clinical studies. The strain Lactobacillus plantarum PS128 was isolated after a rigorous screening process of nearly one thousand strains of bacteria. These strains were tested for potency, effectiveness, and the ability to affect mental wellness. PS128 was proven to strengthen the immune and digestive systems, as well as improve mental health by modulating stress, reducing anxiety, and promoting a balanced mood. Click here for more information about the science of Neuralli. You can view the 12 clinical studies about PS128 here.

How is PS128 different from any other strain of L. plantarum? Will other L. plantarum strains have the same effect?

While many strains of L. plantarum are commercially available as probiotics, the L. plantarum PS128 strain has proved to be neurologically active in preclinical trials.

In general, different strains of a single bacterial species can have very different beneficial effects. For example: L. plantarum UALp-05 may be beneficial for people with IBS. Lactobacillus plantarum LPLDL can help with cholesterol levels. Lactobacillus plantarum TWK10 may help retain muscle mass in aging athletes.

What’s the difference between taking PS128 and eating lacto-fermented vegetables?

PS128 was discovered in spontaneously fermented mustard greens after screening over 1000 lactic acid bacteria for gut-brain potential. There are a lot of foods that contain live microorganisms. However, the CFU count of any specific microorganism strain that happens to be in a fermented vegetable doesn't reach the 30 billion CFU total that is in each capsule of Neuralli. The specificity of strains can vary in sauerkraut, and CFU count may range, for example, from 1,000 to 100 million CFUs of all strains per gram. When you compare this to the 60 billion CFUs of PS128 in the daily serving of Neuralli, it adds up to a minor amount.

Your choice of probiotic should also be based on evidence-based trials of efficacy on specific strains or formulations. In the case of PS128, research-based single-strain probiotics can be particularly powerful, as they are more targeted and offer researched benefits from the specific strain.

What are psychobiotics?

An expansion to the term probiotic, psychobiotics are defined as live microorganisms that when administered at adequate amounts, provide a mental health benefit. Neuralli contains the novel psychobiotic L. plantarum PS128, clinically shown to provide both neurological and mental health benefits, likely due to its influence on the production and/or metabolism of serotonin and dopamine.

What is a medical probiotic?

A medical probiotic is a type of medical food. The term medical food, as defined in the Orphan Drug Act, is "a food which is formulated to be consumed or administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation."

Neuralli is a medical probiotic, specific to neurological and mental health. In Neuralli’s case, this term encompasses Neuralli’s active ingredient L. plantarum PS128 being a probiotic, psychobiotic, and medical food clinically shown to provide neurological and mental health benefits.

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