NeuralliTM is a neurologically active probiotic that works within the gut to enhance mood, mind and movement via the gut-brain axis.
It is specifically formulated as a medical food to assist in the dietary management of neurological conditions such as ASD, PD and ADHD.
Educate yourself. Educate your patients.
- Liu YW, Liong MT, Chung YE, et al. Effects of Lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blind, placebo-controlled trial. Nutrients. 2019,11(4):820. doi: 10.3390/nu11040820.
- Kong XJ, Liu J, Liu K, et al. Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: A randomized, double-blinded, placebo-controlled pilot trial. Nutrients. 2021,13(5):1552. doi: 10.3390/nu13051552.
- Mensi MM, Rogantini C, Marchesi M, et al. Lactobacillus plantarum PS128 and other probiotics in children and adolescents with autism spectrum disorder: A real-world experience. Nutrients. 2021,13(6):2036. doi: 10.3390/nu13062036.
Neuralli is backed by clinical science
The active ingredient in Neuralli is L. plantarum PS128, a probiotic strain of plant origin that balances the levels of neurotransmitters such as serotonin, dopamine, and cortisol.
Three studies of PS128 with autistic children and adolescents indicate it can improve neurological symptoms in some patients.
Two randomized double-blind placebo-controlled clinical studies1,2 and one “real-world study”3 have been published, each by a different research group.
What is Neuralli?
Neuralli is a medical probiotic containing the unique psychobiotic strain L. plantarum PS128 at the same dose utilized in 12 published clinical studies of neurological and mental health conditions.
PS128 is a psychobiotic - “a live organism that when ingested in adequate amounts produces a health benefit in patients suffering from a neurological illness.”
Neuralli is a medical food. The term medical food, as defined in section 5(b) of the Orphan Drug Act (21 U.S.C. 360ee (b) (3)) is "a food which is formulated to be consumed or administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.
How it works
Preclinical research suggests that PS128, the active ingredient in Neuralli, has both probiotic and psychobiotic effects.
Its psychobiotic effects are mediated by the gut-brain axis (GBA), allowing PS128 to influence
the central nervous system without leaving the intestinal lumen.
Read the L. plantarum PS128 Clinical Studies for ASD
Each Neuralli dose contains the same amount of PS128 used in these studies.
Effects of L. plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blinded, placebo-controlled trial (2019)
Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: A randomized, double-blinded, placebo-controlled pilot trial (2021)
L. plantarum PS128 and other probiotics in children and adolescents with autism spectrum disorder: A real-world experience (2021)
Our clinical portfolio doesn’t stop there
PS128 has been studied in other neurological conditions, and additional research is ongoing.
Our science team
At Bened Life, we stand on the shoulders of the microbiome experts at Bened Biomedical, our research-focused parent organization.
Bened Biomedical's R&D team of 6 PhD scientists is led by Professor Ying Chieh Tsai, whose distinguished 30+ year career in microbiology includes serving as the Director of Biochemistry at National Yang-Ming University (NYMU) School of Medicine in Taiwan.
Besides discovering L. plantarum PS128 and other psychobiotic strains, Bened’s scientists have collectively published more than 50 papers concerning the gut microbiome.