Graph showing anxiety decreasing and attention, communication skills, and personal autonomy increasing.

References

12019 randomized double-blind placebo-controlled clinical study (Taiwan)

22021 randomized double-blind placebo-controlled clinical study (USA)

32021 real-world study (Italy)

42023 autism RCT (Taiwan)

52021 Parkinson's single arm study

62022 anxiety controlled study

What the clinical research says about PS128

The probiotic medical food Neuralli MP provides 60 billion CFUs of L. plantarum PS128, and delivers dietary management for autism and Parkinson's disease. Through dietary management, PS128 supports clinically meaningful outcomes in autism and PD.

Three randomized, double-blinded, placebo-controlled studies using PS128 showed reductions in anxiety or anxiety-like behavior in Autistic people.1-3 Physicians observed improvements in attention, communication and personal autonomy in a real-world study.4

In a pilot study with 25 Parkinson's disease patients taking PS128 as dietary management alongside their own therapies, participants noted significant improvements in motor symptoms and quality of life.5

What is Neuralli MP?

Neuralli MP is a probiotic medical food containing the unique psychobiotic strain L. plantarum PS128 at the same amount utilized in nine published clinical studies of neurological and mental health conditions.

PS128 is a psychobiotic – “a live organism that when ingested in adequate amounts produces a health benefit in patients suffering from a neurological illness.”

Neuralli MP is a medical food. The term medical food, as defined in section 5(b) of the Orphan Drug Act (21 U.S.C. 360ee (b) (3)) is "a food which is formulated to be consumed or administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation".

What Other Providers Are Saying

Alicia Lane, NP

Great product and exciting scientific findings. I can’t wait to start recommending it to my patients.

Eric Gordon, MD

Easy partnership process, and highly recommended by our in-house physicians for patients with autism and anxiety.

Kamaljeet Kalsi, DO

I’m excited to recommend Neuralli MP to patients with autism and Parkinson’s.

Julie Burns, MS, RD, CCN

We’ve already seen some patients report feeling less anxiety.

Kirandeep Bath

Excellent customer service and fast response time! I’ve been able to confidently recommend Neuralli MP to my patients, and the outcomes have been very positive. They’ve reported noticeable improvements in mood and increased motivation.

Josh Orlander

I’ve had a great experience with both Neuralli Mood and Neuralli MP in my personal life, and I confidently recommend them to my patients, particularly those living with Parkinson’s and autism. The improvements I’ve seen firsthand, and in my community, speak volumes about the potential of these products.

 

L. plantarum PS128 clinical studies for ASD

Each Neuralli MP serving contains the same amount of PS128 used in these studies.
Get instant access to the full text of all PS128 clinical studies in our Resource Guide.

Effects of L. plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blinded, placebo-controlled trial (2019)

Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: A randomized, double-blinded, placebo-controlled pilot trial (2021)

L. plantarum PS128 and other probiotics in children and adolescents with autism spectrum disorder: A real-world experience (2021)

Probiotic intervention in young children with autism spectrum disorder in Taiwan: A randomized, double-blinded, placebo-controlled trial (2023)

PS128 clinical studies for Parkinson's disease

In a single-arm pilot study, 25 PD participants took PS128 alongside their existing medications for 12 weeks.

Read the clinical study and download the Parkinson’s fact sheet from the Resource Guide page:

How PS128 works

Preclinical and clinical research suggests that PS128, the active ingredient in Neuralli MP, has psychobiotic effects on the brain.

These psychobiotic effects are mediated by the gut-brain axis (GBA), allowing PS128 to influence the brain without leaving the intestinal lumen.

Diagram illustrating neuron communication and brain signaling processes.

A different kind of probiotic company

Bened Life’s exclusive probiotic and postbiotic strains appear to work by sending signals from the gut to the brain.

Get everything you need to recommend Neuralli MP to your patients with our Health Care Provider-exclusive Resource Guide.

A research-driven legacy

At Bened Life, we stand on the shoulders of the microbiome experts at Bened Biomedical, our research-focused parent organization.

Bened Biomedical's R&D team of six PhD scientists is led by Professor Ying Chieh Tsai. His distinguished 30+ year career in microbiology includes serving as the Director of Biochemistry at the National Yang-Ming University (NYMU) School of Medicine in Taiwan.

Besides discovering L. plantarum PS128 and other psychobiotic strains, Bened’s scientists have collectively published more than 50 papers concerning psychobiotics.

Become a Bened Life partner

Already know you want to offer Bened Life products in your clinic or office?
Apply here: