Studies of PS128 as a Medical Food (Related to Neuralli MP)

Clinical studies in people with diagnosed neurological conditions

Autism

Significant improvements for Autistic children taking PS128, more than other probiotics (Real world study)

doi.org/10.3390/nu13062036

Overall improvement for autism patients taking both PS128 and oxytocin (RCT)

doi.org/10.3390/nu13051552

PS128 alleviated ADHD-like and other behaviors in Autistic children (RCT)

doi.org/10.3390/nu11040820

Anxious/depressed score improvements for Autistic preschoolers taking PS128 (RCT)

doi.org/10.1016/j.rasd.2023.102256

Movement improvements using PS128 in Rett's Syndrome (RCT)

doi.org/10.1177/13623613231225899

Attention Support

ADHD symptoms significantly decreased in children with Tourette syndrome taking PS128 (RCT)

doi.org/10.3390/nu13113698

PS128 alleviated ADHD-like and other behaviors in Autistic children (RCT)

doi.org/10.3390/nu11040820

Parkinson’s

Improved motor function and quality of life in Parkinson's patients taking PD treatment and PS128 (Single-arm study)

doi.org/10.3389/fnut.2021.650053

​Stress & Emotional Balance

Improvements in the depression scale and gut microbiota changes, including an increase in the average relative abundance of Akkermansia compared to baseline, were observed. (Single-arm study)

doi.org/10.3390/nu13113731

The effects of PS128 versus placebo in MDD (RCT)

doi.org/10.1016/j.ajp.2024.104210

Preclinical studies

L. plantarum PS128 regulated levels of dopamine in the brain in rats

doi.org/10.1016/j.brainresbull.2019.07.027

PS128 enhanced dopamine and BDNF in the brain in mice

doi.org/10.3390/ijms24076794

PS128 regulated dopamine and serotonin levels, improved anxiety-like behaviors in germ-free mice

doi.org/10.1016/j.bbr.2015.10.046

PS128 lowered anxious behaviors and regulated related brain dopamine and serotonin in mice

doi.org/10.1016/j.brainres.2015.11.018

PS128 increased gut motility and intestinal serotonin in mice

doi.org/10.1007/s12602-021-09814-3

L. plantarum PS128 did not induce adverse effects in a battery of tests and passed standard safety tests

doi.org/10.3390/foods8120668