Studies of PS128™ as a Medical Food (Related to Neuralli™ MP)

Clinical studies in people with diagnosed neurological conditions

Autism

Significant improvements for Autistic children taking PS128™ , more than other probiotics (Real world study)

doi.org/10.3390/nu13062036

Overall improvement for autism patients taking both PS128™ and oxytocin (RCT)

doi.org/10.3390/nu13051552

PS128™ alleviated ADHD-like and other behaviors in Autistic children (RCT)

doi.org/10.3390/nu11040820

Anxious/depressed score improvements for Autistic preschoolers taking PS128™ (RCT)

doi.org/10.1016/j.rasd.2023.102256

Exploring How Probiotics May Support the Gut-Brain Axis in Children and Teens with Autism

doi.org/10.1186/s12888-022-04151-3

What Body Signals May Tell Us About Autism Symptoms and Probiotic Response

doi.org/10.1016/j.jpsychires.2023.08.006

Attention Support

ADHD symptoms significantly decreased in children with Tourette syndrome taking PS128™ (RCT)

doi.org/10.3390/nu13113698

PS128™ alleviated ADHD-like and other behaviors in Autistic children (RCT)

doi.org/10.3390/nu11040820

Parkinson’s

Improved motor function and quality of life in Parkinson's patients taking PD treatment and PS128™ (Single-arm study)

doi.org/10.3389/fnut.2021.650053

​Stress & Emotional Balance

Improvements in the depression scale and gut microbiota changes, including an increase in the average relative abundance of Akkermansia compared to baseline, were observed. (Single-arm study)

doi.org/10.3390/nu13113731

The effects of PS128™ versus placebo in MDD (RCT)

doi.org/10.1016/j.ajp.2024.104210

PS128™ for Stress, Anxiety, and Sleep Support: A Pilot Study in IT Professionals

doi.org/10.3389/fnut.2021.614105

Preclinical studies

PS128™ regulated levels of dopamine in the brain in rats

doi.org/10.1016/j.brainresbull.2019.07.027

PS128™ enhanced dopamine and BDNF in the brain in mice

doi.org/10.3390/ijms24076794

PS128™ regulated dopamine and serotonin levels, improved anxiety-like behaviors in germ-free mice

doi.org/10.1016/j.bbr.2015.10.046

PS128™ lowered anxious behaviors and regulated related brain dopamine and serotonin in mice

doi.org/10.1016/j.brainres.2015.11.018

PS128™ increased gut motility and intestinal serotonin in mice

doi.org/10.1007/s12602-021-09814-3

PS128™ did not induce adverse effects in a battery of tests and passed standard safety tests

doi.org/10.3390/foods8120668