Published, peer-reviewed research on L. plantarum PS128

Clinical studies in people with diagnosed neurological conditions

Autism and other neurodevelopmental conditions

Significant improvements for Autistic children taking PS128, more than other probiotics (Real world study)

doi.org/10.3390/nu13062036

Overall improvement for autism patients taking both PS128 and oxytocin (RCT)

doi.org/10.3390/nu13051552

PS128 alleviated ADHD-like and other behaviors in Autistic children (RCT)

doi.org/10.3390/nu11040820

Anxious/depressed score improvements for Autistic preschoolers taking PS128 (RCT)

doi.org/10.1016/j.rasd.2023.102256

ADHD symptoms significantly decreased in children with Tourette syndrome taking PS128 (RCT)

doi.org/10.3390/nu13113698

Parkinson’s Disease

Improved motor function and quality of life in Parkinson's patients taking PD treatment and PS128 (Single-arm study)

doi.org/10.3389/fnut.2021.650053

​Anxiety and Depression

In a trial of 200 participants with anxiety, the self-rated anxiety score was lower for those taking PS128 in addition to standard treatment versus those taking the treatment alone. (Controlled study)

doi.org/10.9758/cpn.2022.20.3.560

Improvements in the depression scale and gut microbiota changes, including an increase in the average relative abundance of Akkermansia compared to baseline, were observed. (Single-arm study)

doi.org/10.3390/nu13113731

Preclinical Studies

L. plantarum PS128 regulated levels of dopamine in the brain in rats

doi.org/10.1016/j.brainresbull.2019.07.027

PS128 enhanced dopamine and BDNF in the brain in mice

doi.org/10.3390/ijms24076794

PS128 regulated dopamine and serotonin levels, improved anxiety-like behaviors in germ-free mice

doi.org/10.1016/j.bbr.2015.10.046

PS128 lowered anxious behaviors and regulated related brain dopamine and serotonin in mice

doi.org/10.1016/j.brainres.2015.11.018

PS128 increased gut motility and intestinal serotonin in mice

doi.org/10.1007/s12602-021-09814-3

L. plantarum PS128 did not induce adverse effects in a battery of tests and passed standard safety tests

doi.org/10.3390/foods8120668