What to Expect in Your First Month Taking Neuralli

You’ve placed your order and are eagerly awaiting the arrival of your first shipment of Neuralli Medical Probiotic. Here’s what to do next!

1. Store Neuralli in the fridge

When you receive your box, bring it inside as soon as possible and put each of your Neuralli bottles into the refrigerator (they’re heavy, aren’t they?). It’s ok if the inside of the box is not cold. If it’s warm and any included ice packs have melted, don’t worry! 

We work hard to make sure that every time you take Neuralli, you get the full clinical amount of L. plantarum PS128 - that’s 60 billion CFUs per two capsules.

Most probiotic manufacturers are happy just to put the right CFUs in the bottle at the factory and then hope for the best. At Bened Life we go the extra mile to make sure Neuralli is actually as potent when you take it as the label says.

We do that in five ways:

1. Pack each capsule with even more PS128 than promised
2. Ship it to you fast from our US-based warehouses
3. Ship on ice in hot weather to keep Neuralli cooler
4. Use CSP vials to keep every capsule in the bottle moisture-free
5. Remind you to keep Neuralli in its bottle all of the time, and in the refrigerator most of the time

2. Take Neuralli consistently every day

The time of day that you take Neuralli can be whenever works best for you. Some people find they prefer to take two capsules in the morning. Others prefer to take Neuralli in the evening. If you are giving Neuralli to a child, it’s ok to experiment with the best time of day and even to split the dose if necessary. In clinical studies (2-5), parents were given freedom to find the time of day that worked best for their autistic child.

You can open the capsules and mix the powder into a cold, non-acidic drink or cold food if you are not able to swallow a capsule.

When and how you take Neuralli each day is flexible. What’s crucial is that you take Neuralli every day for neurological health benefits, and always keep Neuralli cool and dry. Neuralli should be kept inside its own bottle for highest potency, and it is best stored in the refrigerator.

We recommend setting a reminder on your phone or using a visual cue that helps you to remember Neuralli instead of adding it to a pill box. It’s ok to leave your current bottle of Neuralli out on the counter for up to 14 days, away from direct sunlight and moisture. Make sure to keep any additional bottles in the fridge for long-term storage so they will be at maximum potency on their “Best By” date.

3. Adjust to your new probiotic

Anytime you make a big change to your diet or add a new probiotic, it’s possible your gut may need some time to adjust. You may experience a bit of gas, bloating, or stool consistency changes as you start taking Neuralli. Any GI upset should be mild and should subside within a few days to a week.

If you experience an allergic reaction or gut issues that don’t resolve on their own, stop taking Neuralli and consult your health care provider.

4. Watch for neurological health benefits

Neuralli is a medical probiotic intended to be taken under the supervision of a health care professional for the dietary management of neurological conditions such as autism. Neuralli’s active ingredient is L. plantarum PS128, a unique neurologically active probiotic strain that has been studied in multiple clinical studies, 8 of which are in neurological conditions (to date). PS128 has been found to support:

• Attention in children with neurological conditions - less inattention and less hyperactivity and impulsivity (2-4, 6)
• Mood - less anxiety, and observation of behaviors that indicate less anxiety (2-4, 8)
• Movement in a single-arm PD study - improved akinesia and activities of daily living (1)
• Sleep quality in chronic primary insomnia** - less likely to wake up during deep sleep (7)

(**not a study in people with neurological conditions)

Preclinical studies suggest that these benefits may be attributable to changes in serotonin and/or dopamine signaling or metabolism when taking PS128. Not everyone will experience all types of benefits, and how they look on the outside will vary from person to person.

How can you tell if Neuralli is helping you? We suggest writing down details of struggles you typically encounter with attention, mood, movement, and/or sleep quality. Your doctor may also suggest benefits or potential side-effects of the neurological effects of PS128 that you should watch for.

After 4 or more weeks of taking Neuralli consistently, note any changes. It may also help to ask someone close to you what differences they’ve noticed in you.

Here are some examples of changes Neuralli customers and PS128 clinical study participants and their family members have reported:

• Sleeping through the night more regularly
• An “extra breath” before experiencing an autistic meltdown
• Less sensory overload allowing a wider range of activities
• Shorter duration of “off” periods, and easier movement

To make it easier to track your progress, you can use My Neuralli Journal, a free download from Bened Life. You can download it from our resources page and get started recording your baseline in just a few minutes.

Got questions?

We are happy to answer any questions you may have and really do want to hear about your experience with Neuralli. Please use the Contact page to reach our Customer Happiness Team.

Recommended reading:

Ways to Take Neuralli

How to Get the Most Out of Neuralli

Bened Life’s All-New Packaging: Easier on You & the Planet

Clinical studies cited:

1. Lu CS, Chang HC, Weng YH, et al. The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson's Disease: A Pilot Study. Front Nutr. 2021;8:650053. 
2. Liu Y.-W., Liong M.T., Chung Y.-C.E., et al. Effects of Lactobacillus plantarum PS128 on children with autism spectrum disorder in Taiwan: A randomized, double-blind, placebo-controlled trial. Nutrients. 2019;11:820.
3. Mensi M.M., Rogantini C., Marchesi M., et al. Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience. Nutrients. 2021;13:2036. 
4. Liu Y-W, Wang J-E, Sun F-J, et al. Probiotic intervention in young children with autism spectrum disorder in Taiwan: A randomized, double-blinded, placebo-controlled trial. Research in Autism Spectrum Disorders. 2023;109:102256. 
5. Kong X-J, Liu J, Liu K, et al. Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial. Nutrients. 2021; 13(5):1552. 
6. Wu C-C, Wong L-C, Hsu C-J, et al. Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome. Nutrients. 2021; 13(11):3698.
7. Ho YT, Tsai YC, Kuo TBJ, Yang CCH. Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial. Nutrients. 2021;13(8):2820. 
8. Meng X, Gao Y, Qi H, et al. Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders. Clin Psychopharmacol Neurosci. 2022;20(3):560-566.